1. Withrow SJ, Powers BE, Straw RC, Wilkins RM. Comparative aspects of osteosarcoma. Dog versus man. Clin Orthop Relat Res. 1991(270):159-68.

  2. Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer. 2009;115(7):1531-43.

  3. Spodnick GJ, Berg J, Rand WM, Schelling SH, Couto G, Harvey HJ, et al. Prognosis for dogs with appendicular osteosarcoma treated by amputation alone: 162 cases (1978–1988). J Am Vet Med Assoc. 1992;200(7):995-9.

  4. Khanna C, Lindblad-Toh K, Vail D, London C, Bergman P, Barber L, et al. The dog as a cancer model. Nature Biotechnol. 2006;24(9):1065-6.

  5. Brodey RS, Mc GJ, Reynolds H. A clinical and radiological study of canine bone neoplasms. I. J Am Vet Med Assoc. 1959;134(2):53-71.

  6. Brodey RS, Riser WH. Canine osteosarcoma. A clinicopathologic study of 194 cases. Clin Orthop Relat Res. 1969;62:54-64.

  7. Brodey RS, Sauer RM, Medway W. Canine bone neoplasms. J Am Vet Med Assoc. 1963;143:471-95.

  8. Dorfman SK, Hurvitz AI, Patnaik AK. Primary and secondary bone tumours in the dog. J Small Anim Pract. 1977;18(5):313-26.

  9. Ling G, Morgan J, Pool R. Primary bone rumors in the dog: a combined clinical, radiographic, and histologic approach to early diagnosis. J Am Vet Med Assoc. 1974;165(1):55.

  10. Priester WA, McKay FW. The occurrence of tumors in domestic animals. Natl Cancer Inst Monogr. 1980(54):1-210.

  11. Misdorp W, Hart A. Some prognostic and epidemiologic factors in canine osteosarcoma. J Natl Cancer Inst. 1979;62(3):537-45.

  12. Feeney DA, Johnston GR, Grindem CB, Toombs JP, Caywood DD, Hanlon GF. Malignant neoplasia of canine ribs: clinical, radiographic, and pathologic findings. J Am Vet Med Assoc. 1982;180(8):927-33.

  13. Heyman SJ, Diefenderfer DL, Goldschmidt MH, Newton CD. Canine axial skeletal osteosarcoma. A retrospective study of 116 cases (1986 to 1989). Vet Surg. 1992;21(4):304-10.

  14. Misdorp W. Skeletal osteosarcoma. Animal model: canine osteosarcoma. Am J Pathol. 1980;98(1):285-8.

  15. Ehrhart NP, Ryan SD, Fan TM. Tumors of the skeletal system. Small Anim Clin Oncol, 5th ed. 2013:463-503.

  16. Alexander JW, Patton CS. Primary tumors of the skeletal system. Vet Clin North Am Small Anim Pract. 1983;13(1):181-95.

  17. Ru G, Terracini B, Glickman LT. Host related risk factors for canine osteosarcoma. Vet J. 1998;156(1):31-9.

  18. Straw RC, Withrow SJ. Limb-sparing surgery versus amputation for dogs with bone tumors. Vet Clin North Am Small Anim Pract. 1996;26(1):135-43.

  19. Wolke RE, Nielsen SW. Site incidence of canine osteosarcoma. J Small Anim Pract. 1966;7(7):489-92.

  20. Fenger JM, London CA, Kisseberth WC. Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology. ILAR J. 2014;55(1):69-85.

  21. Kuntz CA. Appendix B: canine osteosarcoma, In: Malawer MM and Sugarbaker PH (eds). Muscoloskeletal cancer surgery – treatment of sarcomas and allied diseases. Springer Publishers. 2001:603-7.

  22. Patnaik AK. Canine extraskeletal osteosarcoma and chondrosarcoma: a clinicopathologic study of 14 cases. Vet Pathol. 1990;27(1):46-55.

  23. Thamm DH, O'Brien MG, Vail DM. Serum vascular endothelial growth factor concentrations and postsurgical outcome in dogs with osteosarcoma. Vet Comp Oncol. 2008;6(2):126-32.

  24. Salm R, Mayes SE. Retroperitoneal osteosarcoma in a dog. Vet Rec. 1969;85(23):651-3.

  25. Ringenberg MA, Neitzel LE, Zachary JF. Meningeal osteosarcoma in a dog. Vet Pathol. 2000;37(6):653-5.

  26. Bech-Nielsen S, Haskins ME, Reif JS, Brodey RS, Patterson DF, Spielman R. Frequency of osteosarcoma among first-degree relatives of St. Bernard dogs. J Natl Cancer Inst. 1978;60(2):349-53.

  27. Kuntz CA, Dernell WS, Powers BE, Withrow S. Extraskeletal osteosarcomas in dogs: 14 cases. J Am Anim Hosp Assoc. 1998;34(1):26-30.

  28. Langenbach A, Anderson M, Dambach D, Sorenmo K, Shofer F. Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986–1996). J Am Anim Hosp Assoc. 1998;34(2):113-20.

  29. Levine RA, Fleischli MA. Inactivation of p53 and retinoblastoma family pathways in canine osteosarcoma cell lines. Vet Pathol. 2000;37(1):54-61.

  30. Kirpensteijn J, Kik M, Teske E, Rutteman GR. TP53 gene mutations in canine osteosarcoma. Vet Surg. 2008;37(5):454-60.

  31. Thomas R, Wang HJ, Tsai PC, Langford CF, Fosmire SP, Jubala CM, et al. Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Res. 2009;17(3):365-77.

  32. Picci P, Vanel D, Briccoli A, Talle K, Haakenaasen U, Malaguti C, et al. Computed tomography of pulmonary metastases from osteosarcoma: the less poor technique. A study of 51 patients with histological correlation. Ann Oncol. 2001;12(11):1601-4.

  33. Waters DJ, Coakley FV, Cohen MD, Davis MM, Karmazyn B, Gonin R, et al. The detection of pulmonary metastases by helical CT: a clinicopathologic study in dogs. J Comput Assist Tomogr. 1998;22(2):235-40.

  34. LaRue SM, Withrow SJ, Wrigley RH. Radiographic bone surveys in the evaluation of primary bone tumors in dogs. J Am Vet Med Assoc. 1986;188(5):514-6.

  35. Berg J, Lamb CR, O'Callaghan MW. Bone scintigraphy in the initial evaluation of dogs with primary bone tumors. J Am Vet Med Assoc. 1990;196(6):917-20.

  36. Hahn KA, Hurd C, Cantwell HD. Single-phase methylene diphosphate bone scintigraphy in the diagnostic evaluation of dogs with osteosarcoma. J Am Vet Med Assoc. 1990;196(9):1483-6.

  37. Jankowski M, Steyn P, Lana S, Dernell W, Blom C, Uhrig J, et al. Nuclear scanning with 99mTc‐HDP for the initial evaluation of osseous metastasis in canine osteosarcoma. Vet Comp Oncol. 2003;1(3):152-8.

  38. Lamb C. Bone scintigraphy in small animals. J Am Vet Med Assoc. 1987;191(12):1616.

  39. Parchman MB, Flanders JA, Erb HN, Wallace R, Kallfelz FA. Nuclear medical bone imaging and targeted radiography for evaluation of skeletal neoplasms in 23 dogs. Vet Surg. 1990;18(6):454-8.

  40. Bergman PJ, MacEwen EG, Kurzman ID, Henry CJ, Hammer AS, Knapp DW, et al. Amputation and carboplatin for treatment of dogs with osteosarcoma: 48 cases (1991 to 1993). J Vet Intern Med. 1996;10(2):76-81.

  41. Cho WH, Song WS, Jeon D-G, Kong C-B, Kim MS, Lee JA, et al. Differential presentations, clinical courses, and survivals of osteosarcomas of the proximal humerus over other extremity locations. Annal Surg Oncol. 2010;17(3):702-8.

  42. Schwarz P, Withrow S, Curtis C, Powers B, Straw R. Partial maxillary resection as a treatment for oral cancer in 61 dogs. J Am Anim Hosp Assoc (USA). 1991.

  43. Wallace J, Matthiesen DT, Patnaik AK. Hemimaxillectomy for the treatment of oral tumors in 69 dogs. Vet Surg. 1992;21(5):337-41.

  44. Hendrix D, Gelatt K. Diagnosis, treatment and outcome of orbital neoplasia in dogs: a retrospective study of 44 cases. J Small Anim Pract. 2000;41(3):105-8.

  45. Baines SJ, Lewis S, White RA. Primary thoracic wall tumours of mesenchymal origin in dogs: a retrospective study of 46 cases. Vet Rec. 2002;150(11):335-9.

  46. Matthiesen DT, Clark GN, Orsher RJ, Pardo AO, Glennon J, Patnaik AK. En bloc resection of primary rib tumors in 40 dogs. Vet Surg. 1992;21(3):201-4.

  47. Montgomery R, Henderson R, Powers R, Withrow S, Straw R, Freund J, et al. Retrospective study of 26 primary tumors of the osseous thoracic wall in dogs. J Am Anim Hosp Assoc (USA). 1993: (29) 68–72.

  48. Pirkey-Ehrhart N, Withrow SJ, Straw RC, Ehrhart EJ, Page RL, Hottinger HL, et al. Primary rib tumors in 54 dogs. J Am Anim Hosp Assoc. 1994;31(1):65-9.

  49. Montinaro V, Boston SE, Buracco P, Culp WT, Romanelli G, Straw R, et al. Clinical outcome of 42 dogs with scapular tumors treated by scapulectomy: A Veterinary Society of Surgical Oncology (VSSO) retrospective study (1995–2010). Vet Surg. 2013;42(8):943-50.

  50. Gamblin RM, Straw RC, Powers BE, Park RD, Bunge MM, Withrow SJ. Primary osteosarcoma distal to the antebrachiocarpal and tarsocrural joints in nine dogs (1980–1992). J Am Anim Hosp Assoc. 1994;31(1):86-91.

  51. Ehrhart N, Dernell W, Hoffmann W, Weigel R, Powers B, Withrow S. Prognostic importance of alkaline phosphatase activity in serum from dogs with appendicular osteosarcoma: 75 cases (1990–1996). J Am Vet Med Assoc. 1998;213(7):1002-6.

  52. Hillers KR, Dernell WS, Lafferty MH, Withrow SJ, Lana SE. Incidence and prognostic importance of lymph node metastases in dogs with appendicular osteosarcoma: 228 cases (1986–2003). J Am Vet Med Assoc. 2005;226(8):1364-7.

  53. Garzotto CK, Berg J, Hoffmann WE, Rand WM. Prognostic significance of serum alkaline phosphatase activity in canine appendicular osteosarcoma. J Vet Intern Med. 2000;14(6):587-92.

  54. Moore AS, Dernell WS, Ogilvie GK, Kristal O, Elmslie R, Kitchell B, et al. Doxorubicin and BAY 12-9566 for the treatment of osteosarcoma in dogs: a randomized, double-blind, placebo-controlled study. J Vet Intern Med. 2007;21(4):783-90.

  55. Kirpensteijn J, Kik M, Rutteman G, Teske E. Prognostic significance of a new histologic grading system for canine osteosarcoma. Vet Pathol Online. 2002;39(2):240-6.

  56. Berg J, Weinstein MJ, Schelling SH, Rand WM. Treatment of dogs with osteosarcoma by administration of cisplatin after amputation or limb-sparing surgery: 22 cases (1987–1990). J Am Vet Med Assoc. 1992;200(12):2005-8.

  57. Maulding G, Matus R, Withrow S, Patnaik A. Canine osteosarcoma. Treatment by amputation and adjuvant chemotherapy using doxorubicin and cisplatin. J Vet Inter Med. 1988;2(4):177-80.

  58. Pinho SS, Carvalho S, Cabral J, Reis CA, Gartner F. Canine tumors: a spontaneous animal model of human carcinogenesis. Transl Res. 2012;159(3):165-72.

  59. Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, Kamal M, et al. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature. 2005;438(7069):803-19.

  60. Lazarides A, Erdmann D, Powers D, Eward W. Custom facial reconstruction for osteosarcoma of the jaw. J Oral Maxillofac Surg. 2014;72(11):2375 e1-10.

  61. Parker HG, Shearin AL, Ostrander EA. Man's best friend becomes biology's best in show: genome analyses in the domestic dog. Annu Rev Genet. 2010;44:309-36.

  62. Rowell JL, McCarthy DO, Alvarez CE. Dog models of naturally occurring cancer. Trends Mol Med. 2011;17(7):380-8.

  63. Maeda J, Yurkon CR, Fujisawa H, Kaneko M, Genet SC, Roybal EJ, et al. Genomic instability and telomere fusion of canine osteosarcoma cells. PLoS One. 2012;7(8):e43355.

  64. Selvarajah S, Yoshimoto M, Ludkovski O, Park PC, Bayani J, Thorner P, et al. Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH. Cytogenet Genome Res. 2008;122(1):5-15.

  65. Sutter NB, Ostrander EA. Dog star rising: the canine genetic system. Nat Rev Genet. 2004;5(12):900-10.

  66. Ostrander EA, Comstock KE. The domestic dog genome. Curr Biol. 2004;14(3):R98-9.

  67. Paoloni M, Davis S, Lana S, Withrow S, Sangiorgi L, Picci P, et al. Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. BMC Genom. 2009;10:625.

  68. Mintz MB, Sowers R, Brown KM, Hilmer SC, Mazza B, Huvos AG, et al. An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. Cancer Res. 2005;65(5):1748-54.

  69. Fossey SL, Liao AT, McCleese JK, Bear MD, Lin J, Li PK, et al. Characterization of STAT3 activation and expression in canine and human osteosarcoma. BMC Cancer. 2009;9:81.

  70. Liao AT, McMahon M, London C. Characterization, expression and function of c-Met in canine spontaneous cancers. Vet Comp Oncol. 2005;3(2):61-72.

  71. MacEwen EG, Kutzke J, Carew J, Pastor J, Schmidt JA, Tsan R, et al. c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells. Clin Exp Metastasis. 2003;20(5):421-30.

  72. Ryu K, Choy E, Yang C, Susa M, Hornicek FJ, Mankin H, et al. Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. J Orthop Res. 2010;28(7):971-8.

  73. Rosenberger JA, Pablo NV, Crawford PC. Prevalence of and intrinsic risk factors for appendicular osteosarcoma in dogs: 179 cases (1996–2005). J Am Vet Med Assoc. 2007;231(7):1076-80.

  74. Phillips JC, Lembcke L, Chamberlin T. A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26. Genomics. 2010;96(4):220-7.

  75. Scott MC, Sarver AL, Gavin KJ, Thayanithy V, Getzy DM, Newman RA, et al. Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. Bone. 2011;49(3):356-67.

  76. Angstadt AY, Thayanithy V, Subramanian S, Modiano JF, Breen M. A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. Cancer Genet. 2012;205(11):572-87.

  77. Loukopoulos P, Thornton JR, Robinson WF. Clinical and pathologic relevance of p53 index in canine osseous tumors. Vet Pathol. 2003;40(3):237-48.

  78. Wunder JS, Gokgoz N, Parkes R, Bull SB, Eskandarian S, Davis AM, et al. TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. J Clin Oncol. 2005;23(7):1483-90.

  79. Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Cancer Treat Res. 2009;152:3-13.

  80. Mendoza S, Konishi T, Dernell WS, Withrow SJ, Miller CW. Status of the p53, Rb and MDM2 genes in canine osteosarcoma. Anticancer Res. 1998;18(6A):4449-53.

  81. Freeman SS, Allen SW, Ganti R, Wu J, Ma J, Su X, et al. Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. Cancer. 2008;113(6):1453-61.

  82. LaRue SM, Withrow SJ, Powers BE, Wrigley RH, Gillette EL, Schwarz PD, et al. Limb-sparing treatment for osteosarcoma in dogs. J Am Vet Med Assoc. 1989;195(12):1734-44.

  83. Withrow SJ, Thrall DE, Straw RC, Powers BE, Wrigley RH, Larue SM, et al. Intra-arterial cisplatin with or without radiation in limb-sparing for canine osteosarcoma. Cancer. 1993;71(8):2484-90.

  84. Kuntz CA, Asselin TL, Dernell WS, Powers BE, Straw RC, Withrow SJ. Limb salvage surgery for osteosarcoma of the proximal humerus: outcome in 17 dogs. Vet Surg. 1998;27(5):417-22.

  85. Rougraff BT, Simon MA, Kneisl JS, Greenberg DB, Mankin HJ. Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. A long-term oncological, functional, and quality-of-life study. J Bone Joint Surg Am. 1994;76(5):649-56.

  86. Thompson JP, Fugent MJ. Evaluation of survival times after limb amputation, with and without subsequent administration of cisplatin, for treatment of appendicular osteosarcoma in dogs: 30 cases (1979–1990). J Am Vet Med Assoc. 1992;200(4):531-3.

  87. Eilber F, Giuliano A, Eckardt J, Patterson K, Moseley S, Goodnight J. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol. 1987;5(1):21-6.

  88. Link MP, Goorin AM, Miser AW, Green AA, Pratt CB, Belasco JB, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med. 1986;314(25):1600-6.

  89. Link MP, Goorin AM, Horowitz M, Meyer WH, Belasco J, Baker A, et al. Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study. Clin Orthop Relat Res. 1991(270):8-14.

  90. Paoloni MC, Mazcko C, Fox E, Fan T, Lana S, Kisseberth W, et al. Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs. PLoS One. 2010;5(6):e11013.

  91. Chawla SP, Staddon AP, Baker LH, Schuetze SM, Tolcher AW, D'Amato GZ, et al. Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas. J Clin Oncol. 2012;30(1):78-84.

  92. Demetri GD, Chawla SP, Ray-Coquard I, Le Cesne A, Staddon AP, Milhem MM, et al. Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy. J Clin Oncol. 2013;31(19):2485-92.

  93. Gordon I, Paoloni M, Mazcko C, Khanna C. The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway. PLoS Med. 2009;6(10):e1000161.

  94. Gordon IK, Khanna C. Modeling opportunities in comparative oncology for drug development. ILAR J. 2010;51(3):214-20.

  95. Lascelles BD, Dernell WS, Correa MT, Lafferty M, Devitt CM, Kuntz CA, et al. Improved survival associated with postoperative wound infection in dogs treated with limb-salvage surgery for osteosarcoma. Ann Surg Oncol. 2005;12(12):1073-83.

  96. Jeys LM, Grimer RJ, Carter SR, Tillman RM, Abudu A. Post operative infection and increased survival in osteosarcoma patients: are they associated? Ann Surg Oncol. 2007;14(10):2887-95.

  97. Wycislo KL, Fan TM. The immunotherapy of canine osteosarcoma: a historical and systematic review. J Vet Intern Med. 2015;29(3):759-69.

  98. Biller BJ, Elmslie RE, Burnett RC, Avery AC, Dow SW. Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Vet Immunol Immunopathol. 2007;116(1-2):69-78.

  99. Rissetto KC, Rindt H, Selting KA, Villamil JA, Henry CJ, Reinero CR. Cloning and expression of canine CD25 for validation of an anti-human CD25 antibody to compare T regulatory lymphocytes in healthy dogs and dogs with osteosarcoma. Vet Immunol Immunopathol. 2010;135(1-2):137-45.

  100. Biller BJ, Guth A, Burton JH, Dow SW. Decreased ratio of CD8+ T cells to regulatory T cells associated with decreased survival in dogs with osteosarcoma. J Vet Intern Med. 2010;24(5):1118-23.

  101. Sherger M, Kisseberth W, London C, Olivo-Marston S, Papenfuss TL. Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs. BMC Vet Res. 2012;8:209.

  102. Goulart MR, Pluhar GE, Ohlfest JR. Identification of myeloid derived suppressor cells in dogs with naturally occurring cancer. PLoS One. 2012;7(3):e33274.

  103. Selmic LE, Lafferty MH, Kamstock DA, Garner A, Ehrhart NP, Worley DR, et al. Outcome and prognostic factors for osteosarcoma of the maxilla, mandible, or calvarium in dogs: 183 cases (1986–2012). J Am Vet Med Assoc. 2014;245(8):930-8.

  104. Sottnik JL, Rao S, Lafferty MH, Thamm DH, Morley PS, Withrow SJ, et al. Association of blood monocyte and lymphocyte count and disease-free interval in dogs with osteosarcoma. J Vet Intern Med. 2010;24(6):1439-44.

  105. Kleinerman ES, Maeda M, Jaffe N. Liposome-encapsulated muramyl tripeptide: a new biologic response modifier for the treatment of osteosarcoma. Cancer Treat Res 1993;62:101-7.

  106. Kurzman ID, MacEwen EG, Rosenthal RC, Fox LE, Keller ET, Helfand SC, et al. Adjuvant therapy for osteosarcoma in dogs: results of randomized clinical trials using combined liposome-encapsulated muramyl tripeptide and cisplatin. Clin Cancer Res. 1995;1(12):1595-601.

  107. Meyers PA, Schwartz CL, Krailo MD, Healey JH, Bernstein ML, Betcher D, et al. Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group. J Clin Oncol. 2008;26(4):633-8.

  108. Daw NC, Neel MD, Rao BN, Billups CA, Wu J, Jenkins JJ, et al. Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. Cancer. 2011;117(12):2770-8.

  109. Paoloni M, Khanna C. Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer. 2008;8(2):147-56.

  110. Rodriguez CO, Jr., Crabbs TA, Wilson DW, Cannan VA, Skorupski KA, Gordon N, et al. Aerosol gemcitabine: preclinical safety and in vivo antitumor activity in osteosarcoma-bearing dogs. J Aerosol Med Pulm Drug Deliv. 2010;23(4):197-206.

  111. Zhang J, Chen X, Kent MS, Rodriguez CO, Chen X. Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor. Mol Cancer Res. 2009;7(1):67-78.

  112. Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, et al. Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency. J Med Chem. 2011;54(5):1233-43.

  113. Rankin KS, Starkey M, Lunec J, Gerrand CH, Murphy S, Biswas S. Of dogs and men: comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma. Pediatr Blood Cancer. 2012;58(3):327-33.

  114. Fieten H, Spee B, Ijzer J, Kik MJ, Penning LC, Kirpensteijn J. Expression of hepatocyte growth factor and the proto-oncogenic receptor c-Met in canine osteosarcoma. Vet Pathol. 2009;46(5):869-77.

  115. Atkinson JM, Falconer RA, Edwards DR, Pennington CJ, Siller CS, Shnyder SD, et al. Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases. Cancer Res. 2010;70(17):6902-12.

  116. Eisenach PA, Roghi C, Fogarasi M, Murphy G, English WR. MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. J Cell Sci. 2010;123(23):4182-93.